Bioavailability of organically bound iodine.

Total serum iodine levels were measured for 24 hr in human subjects following a single, oral, therapeutic dose of organically bound iodine administered as iodinated glycerol. In one volunteer, measurements were taken during continued dosing for 6 days and for 48 hr thereafter. Peak levels were attained 1-2 hr after administration of a single dose, with a gradual fall to almost basal levels by 24 hr. The experiment with continued dosing for 6 days indicated that once peak blood levels were reached, they continued at this concentration until the drug was discontinued; then they progressively dropped to pretreatment figures in about 48 hr. The bioavailability of the iodinated glycerol was demonstrated following aqueous solution, elixir, and tablet formulations. No significant effect on blood thyroxine iodine levels was noted. Keyphrases 0 Iodine, organically bound-bioavailability from iodinated glycerol as aqueous solution, elixir, and tablet formulations, humans Thyroxine-blood levels following administration of aqueous solution, elixir, and tablet formulations of iodinated glycerol, humans Bioavailability-iodine from iodinated glycerol formulated as aqueous solution, elixir, and tablet, humans Any ingested drug whose pharmacological activity is dependent upon reaching the circulating blood should be detectable in the circulation as a basic step in proving potential therapeutic efficacy. The purpose of the present study was to establish the bioavailability of organically bound iodine as iodinated glycerol1 when administered as a tablet or in liquid formulation, the latter as an elixir or aqueous solution.